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Unformatted text preview: Micro Test 4 Immunology *Immunology is a LEARNED process- Recognition of your immunological self occurs at 30 days gestation - Basically your immune system learns what components are you- There are parts of our anatomy developed after 30 days BUT the immune system will NOT recognize these because they were not present when the immune system learned who we were...- So this is an exclusion process where the immune system learns what NOT to respond to...it is designed to respond to things that are foreign based on this learned recognition of self- eg Sympathetic opthalmia- If trauma occurs to one eye this will cause an immune response that invades BOTH eyes... - BUT since the eyes are NOT present at 30 days gestation this immune response would be harmful to the eye that is not infected- SOOO we will take out the bad eye to prevent production of antibodies that would attack the good eye- Random about dizygotic (aka fraternal) twins- One placenta, one circulatory system, two eggs - Since they have the same circulation their immune system will recognize both themselves AND their twin as "self," ie the twins are immunologically identical!!- Therefore in a blood transfusion, even if they were not the same blood type, they could receive each other's blood because it would be recognized by the immune system and no antibodies would be produced- Sequestered tissue = tissue your immune system attacks Varieties of Immune Responses *Protective - What we typically think of when we think of immunity (ie the immune system helping us to eliminate disease) *Neutral- Neither protective or harmful *Harmful- Causes an exaggerated response know as a hypersensitivity ie an allergic response- There are five categories of hypersensitivities but we will talk about those later *Lets look at the bacteria strep. pyrogenes that causes strep throat and scarlet fever (hmmm maybe one of these diseases is the reason TIM SKIPPED CLASS TODAY!!)- It is also responsible for causing post-streptococcal diseases that are NOT infective 1- These are IMMUNE BASED - Rheumatic heart disease- Due to a HARMFUL cross reaction of antibodies that attack the cardiac tissue- Glomerular nephritis (NEUTRAL)- Immune antibody complex gets trapped in the kidney and could lead to subsequent damage- Typically this will cause significant and rapid weight gain (due to fluid accumulation)- So when patients present with these symptoms they will check their AsO titer- The AsO titer indicates an immune response to exoenzyme streptolycin O from strep. pyrogenes- This immune response is neither protective nor harmful BUT is a marker of recent strep. infection- We can check the AsO titer through two blood draws, and compare them to see if it is rising.... a rising titer is indicative of recent exposure... this condition would probably go away on its own upon elimination of the microbe.......
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