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Unformatted text preview: And now.....last but not least...the climax of our notes...... RANDOM CRAP TO KNOW: *Let's talk about E. coli baby Has MANY MANY different types- If it has a capsule...it can cause pneumonia and meningitis- It is found in the GI normal flora where it attaches with pilli- It can cause UTIs if it has pilli and flagella- And, as we discussed before, it is known as hemmoragic e. coli when it has the H 7 O 157 antigen *Some words to know- Bacterosemia (spelling??) means bacteria is present in the blood but not growing- Septosemia means bacteria is GROWING in the bloodstream- Viremia means you have a virus in your blood * Mycoplasma- an example of an organism with no cell wall, has no reaction gr (+) or gr (-), no acid fast results, no shape.....and is called a polymorph or pleomorphin- Note...these organisms survive in humans by stealing our cholesterol (since it does not synthesize its own) and using it to stabalize its cell membrane * TB vaccine = BCG = an attiunated bacteria that has been passed across various media until it loses the genetic factors responsible for its virulence....then when it's put in humans it dies b/c it has been genetically altered. - NOT used in US - we use the PPD skin test only TREATMENT = isoniazid (INH) which interferes of synthesis of mycolic acids...but also causes liver toxicity *Treatment of mycoplasma pneumoniae is erythromycin Micro Study Guide - Test 1 1) Originally people believed in SG and the idea that disease could be passed on by things such as miasms. This lead to misconceptions about how to treat disease. Eventually beliefs changed to the Germ Theory of Disease which states that "a specific disease is caused by a specific type of microorganism." Among the important developments of this time was the idea of nosocomial infection which implies that doctors are in part responsible for the transfer of disease among hospital patients. The idea of hand washing and aseptic techniques were a result of this discovery. In addition the development of sanitation systems around the world occurred to stop the spread of epidemics through contaminated water. Another important development were the Henle-Koch Postulates which use the scientific method and the germ theory of disease to discover causes of diseases. They are: 1 - The organism must be regularly found in the lesions characteristic of the disease. 2 - Isolation in pure culture on an artificial media 3 - Inoculation of an experimental animal produces a similar disease 4 - Re-isolation of the organism is possible from a lesion of the experimental animal NOTE: Chlamedia does not fit the postulates because it cannot be isolated on artificial media!!! (have to have live cell culture) You also have to be careful to have an experimental animal that will respond to the disease (eg - leprosy ...have to use armadillo belly b/c hairless and same temp as humans!) 2 ) Eukaryotic cells:- have nuclear membrane (second barrier to drugs that interfere with DNA synthesis)- have membrane bound (lipid lined) organelles (including more than one...
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This note was uploaded on 04/17/2008 for the course BIOL 438 taught by Professor Ryan during the Spring '08 term at Ferris State.
- Spring '08