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T HIN L AYER C HROMATOGRAPHY OF A NALGESICS Introduction: Over-the-counter analgesics typically contain one or more of the following active ingredients: acetaminophen, aspirin, caffeine, ibuprofen, phenacetin, or salicylamide. Thin layer chromatography (TLC) offers a simple method of analysis for these products. Chromatography is a term that is widely used to describe a family of closely related separation methods. There are many separation methods, but the feature that distinguishes chromatography from other physical and chemical methods of separation is that both a stationary and mobile phase, which are incapable of being mixed, come into contact and the sample to be separated interacts numerous times with these phases. The sample is carried through the system via the mobile phase, and the interactions that occur are due to the differences in the physical and chemical properties that govern the rate at which the individual components of the sample pass over the stationary phase under the influence of the mobile phase. Thin layer chromatography (TLC) is one type of chromatography where the stationary phase is a thin layer of adsorbent particles attached to the solid plate. A small amount of sample is applied (spotted) near the bottom of the plate, and the plate is placed in the mobile phase. This solvent is drawn up by capillary action to a predetermined
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This note was uploaded on 02/02/2009 for the course PHYS 10a taught by Professor Martens during the Spring '07 term at Brandeis.

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