Lec_12 (2) - Lecture 12 Recombination and mobile genetic...

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Lecture 12 Recombination and mobile genetic elements
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Homologous recombination: Exchange of DNA strands across pairs of homologous chromosomes Requires extensive sequence homology between the strands- guides the process 1. DNA repair (DSBs) 2. General recombination during meiosis-crossing over
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The pairing of DNA strands from different DNA molecules is called DNA hybridization and the product is called a DNA heteroduplex.
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MBoc 4 th edition Homologous recombination occurs when two homologous chromosomes Pair and are brought together (with the aid of factors in the cell) It begins with strand invasion-driven by base pairing
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RecA forms a nucleoprotein filament that maintains a region of single- stranded DNA and helps “insert” the single strand into the adjacent chromosome. It carries out strand invasion
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Precise repair of DSBs use recombination
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Figure 5-53 Molecular Biology of the Cell Meiosis generates germ cells containing one maternal or paternal homolog and one sex chromosome per germ cell.
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