Ingestion - PSB3340 27 March 2008 Liver factours: Gastric...

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PSB3340 27 March 2008 Liver factours: Gastric and duodenal satiety are only anticipatory. The last stage of satiety appear to occur in the liver. Insulin - Absorptive phase accompanied by increased level of insulin in the blood. - Tells the brain the body is being fed and needs to be stopped at some point. - Even though the brain doesn’t require insulin to metabolize glucose, it has insulin receptors. - The brain appears to detect levels of insulin in blood. - Crosses the BBB and reaches the hypothalamus, which regulates hunger and satiety - Infusion of insulin into the third ventricle inhibits eating and causes a loss of body weight. Long term Satiety - Body weight appears to be regulated over a long term basis. - When animals are force-fed more than a normal amount, they reduce their food intake once they are permitted to choose how much to eat. - Adipose tissues, amount of fattiness signal how much to consume. - Leptin: hormone secreted by adipose tissue - Signals brain to decrease intake, increase metabolism. - OB gene produces leptin. - Because of a genetic mutation, ob mice are unable to produce leptin. Brain mechanisms - Brain stem plays an important role because of evolutionary history - Lower parts are more involved than upper parts of the brain - Hypothalamus regulates intake of food - Decerebrate rats cannot approach food but can eat liquid foods placed in their mouths o They can distinguish between tastes o They respond to hunger and satiety signals
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Ingestion - PSB3340 27 March 2008 Liver factours: Gastric...

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