Pathophysiology of Agensis of Corpus Callosum

Pathophysiology of Agensis of Corpus Callosum - Katie...

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Katie Stompolis Professor Stewart Clinical Week 3: Pathophysiology make up assignment Birth with the absence of the corpus callosum or agenesis of corpus callosum (AgCC) is a rare neural tube defect affecting less than 1% of the population as of 2014 (Ilik & Bilgilisoy, 2014). However, more cases are being identified with the advanced technology of ultrasounds during pregnancy. (Kulak, Goscik & Smigielska-Kuzia, 2012). AgCC can be seen alone, or with other anomalies. For a majority of cases the cause of AgCC is unknown. It has been associated with several consistent chromosomal rearrangements in more than 20 autosomal and X- linked malformation syndromes (Kulak, Goscik & Smigielska-Kuzia, 2012). Intrauterine infections or maternal alcohol ingestion may also contribute to abnormal development of the fetal brain (Kulak, Goscik & Smigielska-Kuzia, 2012) The corpus callosum is the largest white matter structure in the brain, and connects the left and right hemispheres (Huether & McCane, 2015, pg 203). The corpus callosum is theorized to be integral to cognitive functioning such as intelligence, processing speed, and problem solving capabilities (Paul et al., 2007). However the absence of a corpus callosum has variable
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