PMY 311 Self-Test questions prior to Exam 1 20151.Lidocaine is a perfectly effective drug for treating cardiac arrhythmias when administered intravenously. It is ineffective when administered orally. The best explanation for this difference is that when administered orally the drug:A.Causes gastrointestinal bleeding.B.Absorbed but does not reach the heart.C.Is inactivated as a result of first-pass metabolism.D.Is 95% plasma protein bound.A.Eliminated through the kidney.
2.RE: Routes of administration. Given the following table with 5 groupings—route of administration: utility; limitations. If four are correct and one is incorrect, select the incorrect lettered choice. If four are incorrect and one is correct, then select the incorrect lettered choice. 3.The elimination rate of a drug is:
Route of administrationUtilityLimitationsASubcutaneoussuitable for some highly soluble suspensionsslow onset but useful for administration of large volumesBOral ingestionsimple, convenient and economicalbioavailability can be erraticCIntravenousvaluable for emergency use; high bioavailability, permits titration of dosagenot reversible, can produce toxi-city at peak concentrations, and