PMY 311 Review Questions for Dr Rabin’s 1stExam1.What effect would administration of a drug by IV vs. PO have on ED50, KD, and on intrinsic activity? What would the dose-response curves look like?2.Drug X is a weak acid with a pKa of 5.5 that binds to its receptor via ionic bonds. What would be the effects on ∆G and KDif binding occurred at pH= 7.4 and at pH= 4? 3.If Drug Y were a weak base with a pKa of 8.2 that binds to its receptor via ionic bonds, what would be the effects on ∆G and KDif binding occurred at pH= 7.4 and at pH= 9.4?4.Plot the concentration-response curve for a partial agonist in the absence and presence of a agonist at 20* KD5.Plot the dose-response curves for an agonist +an allosteric modulator that:a.increases affinityb.reduces efficacy5. If curve A is for a full agonist, provide possible explanations for curves B, C and E.6. If line C shows the effects of an agonist alone, which line would be the effect of the agonist + a competitive antagonist?