Assignment_2_instructions_due_4_28_2015 - Assignment II(Due...

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16 7 11 The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site Gregory M. Anstead, Kathryn E. Carlson and John A. Katzenellenbogen Steroids 62:268-303, 1997 (PDF loaded in Ublearns) Assignment II (Due 04/28/2014 - Tuesday)
Homework Assignment 2 Using the highlighted text from the paper The estradiol pharmacophore : Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site Gregory M. Anstead, Kathryn E. Carlson and John A. Katzenellenbogen Steroids 62:268-303, 1997 (uploaded in UBLEARNS) comment on the effect of functional group substitutions on 7th, 11th and 16th position of estrogen. Use relative binding affinities as a comparison tool. Task1: Identify the best and the worst substitution Task2: Suggest a functional group that might enhance binding based on what you learned in the previous class lectures.
Position Best Substitution Worst Substitution 11β Larger, nonpolar substituents;

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