Lect 25 - 2003 C. 1 Cancer Genetics I I Bio Sci 97 Lecture...

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Unformatted text preview: 2003 C. 1 Cancer Genetics I I Bio Sci 97 Lecture 25 Dr. Carrie Brachmann Office hours this week--Weds 2-3pm Nat Sci I lobby cbrachma@uci.edu reading lect 26: H& J ch 14 2003 C. 2 Outline Cancer Mutation, mutation, mutation How to be a successful cancer cell Genetic instability I nherited predisposition p53 Cancer therapies 2003 C. 3 The successful cancer cell is a somatic cell that accumulates mutations that specifically bestow cancer characteristics on the cell. These characteristics are: 2003 C. 4 How to be a successful cancer cell Hanahan, D., and Weinberg, R.A., The Hallmarks of Cancer, Cell 100, 57-70 (2000) 2003 C. 5 First requirement Activated Oncogene Proto-oncogene promotes cell division or prevents apoptosis-->gas Therefore: mutations in an oncogene are dominant, gain-of-function mutations-->gas pedal down 2003 C. 6 Second requirement Activated Oncogene + Inactivated Tumor Suppressor Gene The tumor suppressor gene normally acts to prevent cell division or promote apoptosis-->brakes Therefore: mutations in a tumore suppressor gene are recessive loss-of-function-->brakes broken 2003 C. 7 Third requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis Apoptosis is the normal process of a cell killing itself due to DNA damage accumulation or inappropriate cell division. Therefore: mutations can be recessive l-o-f to remove pro- apoptotic proteins or dominant g-o-f to keep anti-apoptotic (i.e. pro-survival) proteins around. 2003 C. 8 Fourth requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis + Immortal A cancer cell divides indefinitely. Reactivates telomerase to keep telomeres from shortening. 2003 C. 9 Fifth requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis + Immortal + Vascularize Cancer cells recruit blood vessels to bring necessary oxygen and nutrients to a tumor 2003 C. 10 Sixth requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis + Immortal + Vascularize + Metastasize 2003 C....
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This note was uploaded on 04/15/2008 for the course BIO SCI 98 taught by Professor Goulding during the Spring '08 term at UC Irvine.

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Lect 25 - 2003 C. 1 Cancer Genetics I I Bio Sci 97 Lecture...

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