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Lect 25 - ©2003 C 1 Cancer Genetics I I Bio Sci 97 Lecture...

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Unformatted text preview: ©2003 C. 1 Cancer Genetics I I Bio Sci 97 Lecture 25 Dr. Carrie Brachmann Office hours this week--Weds 2-3pm Nat Sci I lobby [email protected] reading lect 26: H& J ch 14 ©2003 C. 2 Outline • Cancer • Mutation, mutation, mutation • How to be a successful cancer cell • Genetic instability • I nherited predisposition • p53 • Cancer therapies ©2003 C. 3 The successful cancer cell is a somatic cell that accumulates mutations that specifically bestow “cancer” characteristics on the cell. These characteristics are: ©2003 C. 4 How to be a successful cancer cell Hanahan, D., and Weinberg, R.A., The Hallmarks of Cancer, Cell 100, 57-70 (2000) ©2003 C. 5 First requirement Activated Oncogene Proto-oncogene promotes cell division or prevents apoptosis-->“gas” Therefore: mutations in an oncogene are dominant, gain-of-function mutations-->”gas pedal down” ©2003 C. 6 Second requirement Activated Oncogene + Inactivated Tumor Suppressor Gene The tumor suppressor gene normally acts to prevent cell division or promote apoptosis-->”brakes” Therefore: mutations in a tumore suppressor gene are recessive loss-of-function-->”brakes broken” ©2003 C. 7 Third requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis Apoptosis is the normal process of a cell killing itself due to DNA damage accumulation or inappropriate cell division. Therefore: mutations can be recessive l-o-f to remove pro- apoptotic proteins or dominant g-o-f to keep anti-apoptotic (i.e. pro-survival) proteins around. ©2003 C. 8 Fourth requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis + Immortal A cancer cell divides indefinitely. Reactivates telomerase to keep telomeres from shortening. ©2003 C. 9 Fifth requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis + Immortal + Vascularize Cancer cells recruit blood vessels to bring necessary oxygen and nutrients to a tumor ©2003 C. 10 Sixth requirement Activated Oncogene + Inactivated Tumor Suppressor Gene + Evade Apoptosis + Immortal + Vascularize + Metastasize ©2003 C....
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Lect 25 - ©2003 C 1 Cancer Genetics I I Bio Sci 97 Lecture...

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