Lect 19 - 1 Gene Linkage and Gene Mapping Bio Sci 97...

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©2003 C. 1 Gene Linkage and Gene Mapping Bio Sci 97 Lecture 19 Dr. Carrie Brachmann Department of Developmental and Cell Biology cbrachma@uci.edu
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©2003 C. 2 back to fruit flies… take 2 autosomal genes: pr + = red eyes, pr = purple eyes vg + =normal wings, vg = tiny wings both wild-type alleles are dominant Cross 1: Are pr and vg in the same chromosome? pr/ pr vg/ vg X pr + / pr + vg + / vg + purple eyes, tiny wings red eyes, normal wings Parents
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©2003 C. 3 pr + = red eyes, pr = purple eyes vg + =normal wings, vg = tiny wings both wild-type alleles are dominant pr/ pr vg/ vg X pr + / pr + vg + / vg + F1 pr + / pr vg + / vg pr + / pr vg + / vg red eyes normal wings red eyes normal wings Does this tell us if pr and vg are in the same chromosome? If they are and a cross-over occurred between pr and vg, could we tell? P
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©2003 C. 4 Cross 1: Are pr and vg in the same chromosome? pr/ pr vg/ vg X pr + / pr + vg + / vg + pr + / pr vg + / vg X pr/ pr vg/ vg !! testcross to doubly recessive male !! red, normal pr+ vg+ 1339 purple, tiny pr vg 1195 red, tiny pr+ vg 151 purple, normal pr vg+ 154 these are the genotypes of the maternal gametes, inferred from the F2 phenotype parental types 89% recombinant types 11% NOT equal freq’s, so LINKED F1 red, normal purple, tiny 2839 P
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©2003 C. 5 Cross 2: what if pr and vg recessive alleles are in trans? pr + / pr + vg/ vg X pr/ pr vg + / vg + pr + / pr vg + / vg X pr/ pr vg/ vg P F 1 !! testcross to doubly recessive male !! red, normal
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Lect 19 - 1 Gene Linkage and Gene Mapping Bio Sci 97...

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