Chemical transmission of Neurons

Chemical transmission of Neurons - Lecture 5...

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Unformatted text preview: Lecture 5 Neurotransmission Action potential (electrical signal) Action potential (electrical signal) converted to a chemical signal (neurotransmitter) converted back to a electrical signal back to a electrical signal Neurotransmission Otto Loewi's Experiment Question 1920s: was the synapse signal bioelectrical or chemical ? Neurotransmission Requires 2 neurons, minimum: 1. Presynaptic neuron cell sending the signal 1. Postsynaptic neuron cell receiving the signal Synaptic cleft- a relatively wide space separating the pre- and post-synaptic neurons. Synaptic vesicles- membrane bound organelles in the presynaptic terminal contain one or several different neurotransmitters Calcium channels calcium, Ca++, is critical for the release of all neurotransmitters. Synapse Structure S y n a p t i c c l e f t S y n a p t i c c l e f t Synapse Structure Electron Electron microscope microscope photo of an photo of an actual actual synapse synapse Magnification ~ 35,000 x Axodendritic Axosomatic Axoaxonic Axodendritic Axosomatic Axoaxonic Types of synapses/connections between neurons...
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This note was uploaded on 04/15/2008 for the course NROSCI 0081 taught by Professor Armandosignore during the Spring '08 term at Pittsburgh.

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Chemical transmission of Neurons - Lecture 5...

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