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Unformatted text preview: Differentiation Structure Males Females Genital tubercle Glans penis Clitoris Urethral fold Penile urethra Labia minor Labioscrotal swelling Scrotum Labia majora Causes of hermaphroditism 1. Sex chromosomes imbalance (True hermaphroditism) This occurs from a union of male and female zygotes at the morula stage, or from a mitotic mistake early in development. Genotype is xy/xx, or xy/xo 2. Masculinization of a genetic female. a. occurs at 8-13 weeks. b. from adrenal tumor in fetus (excess androgens) or c. excess maternal androgens- from a tumor- latrogenic- given hormones for some medical reason. 3. Feminization of genetic males a. defective testis development. b. androgen insensitivity (testicular feminizing syndrome) 4. Pseudohermaphroditism: missing a gene to turn testosterone to dihydrotestosterone in the fetus....
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- Spring '99