Course Hero Logo

lecture 2 IMM.docx - lecture 2 – innate immunity : the...

Course Hero uses AI to attempt to automatically extract content from documents to surface to you and others so you can study better, e.g., in search results, to enrich docs, and more. This preview shows page 1 - 3 out of 16 pages.

lecture 2 – innate immunity : the first line of defense toinfection pt. 1(recall)EHRLICH– “ side chain theory” to explain the role of humoral factors in immunityMETCHNIKOFF– for his discovery of phagocytosis to explain the role of cellular components inimmunityboth won the Nobel Prize for medicine in1908how do antitoxins work?PAUL EHRLICH, Nobel Laureate 1908-antitoxins are receptors (antibodies) with astructural complementarity to toxins (“lockand key”) ;proved correct-binding of an infectious agent to a cell-bound receptor leads to the production andrelease of more of the bound receptors ;proved correct-he thought that cells express severaldifferent “anti-toxins”, each of which couldbe selected by different antigens ;provedincorrect1957:EHRLICH’s selection theory revised :FRANKMACFARLANE BURNETproposes the “clonal selection hypothesis”eachantibodyis thespecific product of a cell, and that product ispresented on the cellsurface(as anEhrlich-type receptor)antigen reacts with any cells that carry appropriate specific receptors, toinducetheactivation of these cells toproliferationanddifferentiationsome of the cells and their daughters differentiate to formclones of antibody-formingcells
how does a microbe cause disease?

Upload your study docs or become a

Course Hero member to access this document

Upload your study docs or become a

Course Hero member to access this document

End of preview. Want to read all 16 pages?

Upload your study docs or become a

Course Hero member to access this document

Term
Fall
Professor
N/A
Tags
PAMPs

Newly uploaded documents

Show More

Newly uploaded documents

Show More

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture