Fetal growth - Mistakes in organogenesis 1 in 500 babies...

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Bi Sci 001 Wednesday March 31, 1999 Announcements: Lecture notes: Fetal growth Week 8 or 9 through birth the baby is called a fetus. There is a fine tuning of most organs. "Minor" birth defects develop now. The face and genital mature during this period. This is a period of rapid growth. (1/2 of all infant deaths are from low birth weight) Conception to birth About 266 days 38 weeks From 1 cell to 1 million million (yes 1 million million cells) cells. Estimates are that over 60% of conceptions do not make it to birth. One half of these have chromosome problems: Mistakes in the genetic code. There are over 3,00 genetic diseases. Mistakes in gastrulation - Siamese twins: 1 in 100,000 births
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Unformatted text preview: Mistakes in organogenesis - 1 in 500 babies are born with neural tube defects. Three percent of babies born have serious defects. Events in Development (and areas of problems with development) Cell division: mutations (genetic abnormalities) Cell migrations: entire tissues migrate from one site to another. Example: neural tube defects: mistakes result in spina bifida. Cells move in response to chemical cues and "adhesive" cues. Controlled cell death: (elimination of tissue not needed in adult) Examples: tissue between fingers and puppies born with "eyes shut". Pattern formation: arm vs. leg upper arm vs. leg finger vs. toe Not too many mistakes here in humans....
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