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Unformatted text preview: Mistakes in organogenesis - 1 in 500 babies are born with neural tube defects. Three percent of babies born have serious defects. Events in Development (and areas of problems with development) Cell division: mutations (genetic abnormalities) Cell migrations: entire tissues migrate from one site to another. Example: neural tube defects: mistakes result in spina bifida. Cells move in response to chemical cues and "adhesive" cues. Controlled cell death: (elimination of tissue not needed in adult) Examples: tissue between fingers and puppies born with "eyes shut". Pattern formation: arm vs. leg upper arm vs. leg finger vs. toe Not too many mistakes here in humans....
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- Spring '99