GenExam2key - .Is it possible that this disorder is...

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Unformatted text preview: .Is it possible that this disorder is inherited as an X-linked dominant? F1. Yes, All matings and resulting offspring are consistent with X-linked dominant inheritance F2. No, the mating of 1-1 and 1-2 and resulting offspring contradict X-linked dominant F3. No, the mating of 1-5 and 1-6 and resulting offspring contradict X-linked dominant T4. No, the mating of 11-1 and 11-2 and resulting offspring contradict X-linked dominant T5. No, the mating of 11-3 and 11-4 and resulting offspring contradict X-linked dominant Is it possible that this disorder is inherited as an autosomal dominant? T6. Yes, All matings and resulting offspring are consistent with autosomal dominant F7. No, the mating of 1-1 and 1-2 and resulting offspring contradict autosomal dominant F8. No, the mating of 1-5 and 1-6 and resulting offspring contradict autosomal dominant F9. No, the mating of 11-1 and 11-2 and resulting offspring contradict autosomal dominant F10. No, the mating of 11-3 and 11-4 and resulting offspring contradict autosomal dominant If this is an autosomal recessive who are definitely carriers? Tl 1. 1-4 F12. 1-5 T13. ll-1 T14. 11-4 T15. 11-6 T16. Ill-4 (F if you took exam Thurs or Fri) T17. Ill-5 If this was an X-linked recessive, and IV-2 and IV-3’s first child is an affected son, who in this pedigree are definitely carriers? F18. 1-5 T19. ||-1 T20. II-4 T21. II-6 T22. III-5 T23. III-8 F24. IV-4 You have a family that suffers from a late onset disorder, which means that people with the mutation begin to develop symptoms in their 405. In this pedigree, Individuals in the first two generations are old enough to either display symptoms or not. Individuals in generation three and four, may or may not develop symptoms as they age. B 25. Which form of inheritance would result in the most people definitely developing symptoms? a. autosomal dominant b. x-linked dominant c. autosomal recessive d. X-linked recessive e. two forms of inheritance have the same risk Under which of the following conditions would there be a 25% risk of developing symptoms for the given individual? F26. For Individual IV-2 if this is X-linked recessive T27. For Individual IV-3 if this is autosomal dominant F28. For Individual IV-2 if this is X-linked dominant F29. For Individual IV-1 if this is autosomal recessive E30. If this is an X-linked recessive disorder, what is the chance that individuals 111-4 and 111-5 will have an affected son? a. 1/4 b. 1/8 c. 1/16 d. 1/32 e. none of the above E31. If this is an X-Iinked recessive disorder, what is the chance that individuals IV-1 and IV-2 will have an affected daughter? a. 1/4 b. 1/8 c. 1/16 d. 1/32 e. none of the above D32. If this is an autosomal dominant disorder, what is the chance that individual IV-1 will develop symptoms? a. more than 50% b. 50% c. between 50 and 25% d 25% e. less than 25% Your graduate student decides to run some genetic testing on your family to further identify the type of inheritance so you can make a more accurate prediction of risk. Your student leaves you this set of results, and a note that says that the disease in this family shows allelic heterogeneity suggesting that the two people affected in the first generation have different mutations (same disease). The note also says Individuals I-2 and 111-5 are genotypically normal individuals. Thick bands on the gel are twice the amount of the thin bands. DNA I—1 I-2 l-3 "-1 "—2 "-4 "-5 III-2 III-3 III—4 III-5 mRNA l—1 I—E Hi "-1 "-2 II-4 II-5 III-2 III-3 III—4 III-5 Protein H H! H! II—1 ll-E II-4 ll-5 Ill—2 III-3 Ill-4 Ill-5 Based on all the information available to you about this family the mode of inheritance of this disease is? F33. Autosomal T34. X-linked F35. Y-linked T36. Recessive F37. Dominant A38. Does this disorder show any signs of incomplete penetrance? a. yes b. no What can be said about the type of mutation Individual H has? F39. Could be a nonsense mutation F40. Could be a sense mutation F41. Could be a promoter mutation F42. Could be a deletion in the coding region T43. Could be an insertion in the coding region T/ F 44. Could be an error in splicing How about the type of mutation in individual |-3? F45. Could be a nonsense mutation F46. Could be a sense mutation T47. Could be a promoter mutation T/ F 48. Could be a deletion in the coding region F49. Could be an insertion in the coding region T/ F50. Could be an error in splicing Who in this pedigree has all of their alleles for this gene mutated? T51. I-l T52. |-3 T53. Il-l T54. "-5 F55. |||-2 T56. |||-3 T57. |||-4 The gene regions shown in the following table are from the lac operon. The symbols represent the Lacl, LacO, and LacZ although not necessarily in that order. A + means B-gal is produced, a - means B-gal is not produced. Genotype Lactose absent Lactose Present a- b+ c+ + + a+ b+ c- + + a+ b- c- - - a+ b-c+ /a-b+ c- + + a+ b+ c+/a-b-c- - + a+ b+ c-/a-b-c+ - + a-b+ c+/a+ b-c- + + C58. Which of the following is Lacl? a. a b. b c. c B59. Which of the following is LacZ? a. a b. b c. c A60. Which of the following is LacO? a. a b. b c. c You have a series of partial diploid cells: Strain t |- P- Oc Z+ Y+ / |+ P+ O+ Z- Y- Strain 2 Is P+ O+ Z+ Y- / |+ P+ O+ Z- Y+ Strain 3 |+ P+ Oc Z+ Y- / |+ P+ Oc Z- Y+ Strain 4|- P+ O+ Z- Y+ / |- P+ O+ Z+ Y- Strain 5 Is P+ Oc Z+ Y- / |- P+O+ Z- Y+ Which of the strains is B-gal expression not dependent on the presence of lactose? T/F6l. Strain l T/ F62. Strain 2 T63. Strain 3 T64. Strain 4 T65. Strain 5 Which of these strains show normal inducible expression of B-gal and permease? F66. Strain 1 F67. Strain 2 F68. Strain 3 F69. Strain 4 F70. Strain 5 Which of the following mutations would result in a decrease in the production of B-gal? T71. Deletion in the LacY gene T72. Amorphic mutation in the crp gene F73. Constitutive mutation in the adenylate cyclase gene (AC makes cAMP from ATP). F74. Mutation that lowers the affinity of the binding of the repressor to the operator T75. Hypomorphic mutation in the LacZ gene ...
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