Characteristics of a Cancer cell

Characteristics of a Cancer cell - Bi Sci 001 Monday April...

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Bi Sci 001 Monday April 26,1999 Announcements: Lecture notes: Characteristics of a Cancer cell 1. Profound abnormalities in the plasma membrane. a. increased permeability b. increased transport c. missing, altered, or new membrane proteins. d. diminished capacity for adhesion and recognition at the level of the plasma membrane. 2. Profound changes in the cytoplasm a. cytoskeleton becomes disorganized b. changes in enzyme activity c. increased reliance on glycolysis 3. Abnormal growth and division patterns a. Inhibitions on overcrowding are missing. b. Cells don't stop dividing (the average cell can divide about 50 times then it dies) c. Cells don't differentiate into the recognizable tissues of that organ. d. Cells often don't perform the functions of that cell type. e. Most "solid tumors" can vascularize themselves by secreting a growth factor to cause nearby blood vessels to branch into the tumor. 4. Cancer cells can move! a. Because they don't adhere well, they can break away and travel in
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blood and lymph.
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  • Spring '99
  • Schlegel
  • Oncology, cancer cells

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