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2007%20Chapter%208%20Olfaction%20Supplemental%20Images

2007%20Chapter%208%20Olfaction%20Supplemental%20Images -...

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Chemical senses : Olfaction Ch. 8
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Olfactory Bipolar receptor cells
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OR CNG ACIII Ca 2+ -activated Cl - channel α β γ Odorant /Pheromone cAMP ATP Olfactory sensory neuron 8. Calcium Activates a Ca 2+ -gated chloride channel. Na + Ca2+ Cl - G olf 1. Odorant binds to receptor 2. G olf binds to receptor 3. Alpha subunit and Beta-Gamma subunits split 4. Alpha subunit binds to adenylyl cyclase III 5. ACIII converts ATP to cAMP 6. cAMP binds to a cyclic nucleotide gated (CNG) channel, non-selective cation 7. CNG channel allows Ca 2+ and Na + into the cell Odor response Na + Na + Ca2+ Ca2+ Ca2+ Ca2+ Cl - Cl - Cl - Cl - Cl - Cl -
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Termination of Signal OR CNG ACIII Ca 2+ -activated Cl - channel α β γ Odorant /Pheromone cAMP ATP G olf 1. Removal of odorant 2. Inactivation of α –subunit + cAMP 3. CNG closes + Ca 2+ influx 4. Close Ca 2+ - gated Cl - channel 5. Removal of Ca 2+ via Na + /Ca 2+ Exchanger. Ca 2+ Na+ Na + /Ca 2+ Exchanger cAMP
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Adaptation on the cellular level: I OR CNG ACIII Ca 2+ -activated Cl - channel α β γ Odorant /Pheromone cAMP ATP Calmodulin G
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