2007%20Chapter%208%20Olfaction%20Supplemental%20Images

2007 Chapter 8%2 - Chemical senses Olfaction Ch 8 Olfactory Bipolar receptor cells Ca2 Olfactory sensory neuron Odorant/Pheromone Ca2 Ca2 Na Ca2 Na

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Chemical senses : Olfaction Ch. 8
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Olfactory Bipolar receptor cells
Background image of page 2
OR CNG ACIII Ca 2+ -activated Cl - channel α β γ Odorant /Pheromone cAMP ATP Olfactory sensory neuron 8. Calcium Activates a Ca 2+ -gated chloride channel. Na + Ca2+ Cl - G olf 1. Odorant binds to receptor 2. G olf binds to receptor 3. Alpha subunit and Beta-Gamma subunits split 4. Alpha subunit binds to adenylyl cyclase III 5. ACIII converts ATP to cAMP 6. cAMP binds to a cyclic nucleotide gated (CNG) channel, non-selective cation 7. CNG channel allows Ca 2+ and Na + into the cell Odor response Na + Na + Ca2+ Ca2+ Ca2+ Ca2+ Cl - Cl - Cl - Cl - Cl - Cl -
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
OR CNG ACIII Ca 2+ -activated Cl - channel α β γ Odorant /Pheromone cAMP ATP G olf 1. Removal of odorant 2. Inactivation of α –subunit + cAMP 3. CNG closes + Ca 2+ influx 4. Close Ca 2+ - gated Cl - channel 5. Removal of Ca 2+ via Na + /Ca 2+ Exchanger. Ca
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/18/2008 for the course BIOL 261 taught by Professor Delay during the Spring '08 term at Vermont.

Page1 / 10

2007 Chapter 8%2 - Chemical senses Olfaction Ch 8 Olfactory Bipolar receptor cells Ca2 Olfactory sensory neuron Odorant/Pheromone Ca2 Ca2 Na Ca2 Na

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online