2007%20Additional%20K%20and%20Ca%20currents%20supplemental%20images

2007%20Additional%20K%20and%20Ca%20currents%20supplemental%20images

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Additional K and Ca 2+ currents Not in Bear et al. text.
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Characteristics: Transient (what do these properties say about the channel?) Rapid activation (left: Voltage clamp) Rapid inactivation Ball and chain model (Shaker and sisters Shab, Shaw and Shal) Function: Delays onset of AP, increases interspike interval. (I K unaffected) I A Potassium Current
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Function: Basis for I C potassium current Characteristics: Voltage-sensitive Ca 2+ channels I L Calcium Current I L
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Function: Repolarization Increases AP interspike interval. Characteristics: Voltage-sensitive. Repetitive AP Blocking Ca 2+ - activated K channels and thus I C Cd 2+ . TEA
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Unformatted text preview: I C Calcium-activated Potassium Current (TEA: tetraethylammonium) Control = I K + I C + I L 0.5 mM Cd 0.5 mM Cd + 10 mM TEA Combined I C and I L currents Combined effects of I C and I L currents: 1. Hyperpolarization. 2. Duration 3. I K Removing calcium: AP 1. Hyperpolarization 2. Duration. 3. I K 1 2 3 I M Potassium current Cells with M-type potassium channels often fire tonically if I M current is shut off. Functions of I M : Characteristics: Voltage-activated/voltage sensitive Depolarization RMP. Slow to open ACh activation of m uscarinic receptors Preganglionic cells of sympathetic ganglia....
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2007%20Additional%20K%20and%20Ca%20currents%20supplemental%20images

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