Alcohol - Lecture 9 Alcohol Alcohol - CNS depressant -...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 9 Alcohol
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Alcohol - CNS Alcohol - CNS depressant depressant - Sedative/Hypnotic drugs - others include barbiturates,methaqualone - Can - initially - stimulate = Biphasic Effect -Fermentation - Alcohol in wine Alcohol in wine - interaction of yeast + sugar in fruits interaction of yeast + sugar in fruits Alcohol in beer and distilled spirits\ Alcohol in beer and distilled spirits\ - interaction of yeast and sugar from grains interaction of yeast and sugar from grains
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Most alcohol sold in units amounting to approx. 13.4 grams, or ~ 0.5 oz. 12 oz. Beer 1.5 oz. Spirits 5 oz. wine
Background image of page 4
Pharmacology of Alcohol 1. Mouth: alcohol enters the body. 1. Stomach: some alcohol (20%) gets into the bloodstream in the stomach, but most goes on to the small intestine. 1. Small Intestine: alcohol enters the bloodstream through the walls of the small intestine (80%). 1. Heart: pumps alcohol throughout the body. 1. Brain: alcohol reaches the brain. 1. Liver: alcohol is oxidized by the liver at a rate of about 0.5 oz per hour. Alcohol is converted into water, carbon dioxide and energy.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Alcohol: Rate of Absorption - depends largely on condition of stomach - empty - "buzz" - full - delayed absorption - concentration of alcohol in beverage consumed - 80 proof liquor vs. 12 oz. Glass of wine 12 oz. Glass of wine - rate of consumption - carbonation e
Background image of page 6
Alcohol: Distribution - lipid and water soluble How does this impact absorption? - easily passes BBB ‘That drink went right to my head!’ ‘That drink went right to my head!’ - 90% of alcohol in blood reaches the brain almost immediately – Why so fast?? - equilibrium eventually reached… even distribution throughout the body - alcohol passes blood-placental barrier
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Ethanol Acetaldehyde* Acetic Acid CH 3 CH 2 OH CH 3 CH O CO 2 H 2 O + Alcohol dehydrogenase Aldehyde dehydrogenase Spontaneous CH 3 C OH O Alcohol: Metabolism * This chemical will make you feel ill if it accumulates to a high enough concentration.
Background image of page 8
Acetaldehyde* Acetic Acid CH 3 CH 2 OH CH 3 CH O CO 2 H 2 O + Alcohol dehydrogenase Aldehyde dehydrogenase Spontaneous CH 3 C OH O Alcohol: Metabolism * This chemical will make you feel ill if it accumulates to a high enough concentration. CytP450
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/15/2008 for the course NROSCI 0081 taught by Professor Armandosignore during the Spring '08 term at Pittsburgh.

Page1 / 38

Alcohol - Lecture 9 Alcohol Alcohol - CNS depressant -...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online