Nicotine - Nicotine "Smoking is a custom loathsome to...

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Nicotine Nicotine "Smoking is a custom loathsome to the eye, hateful to the nose, harmful to the brain, dangerous to the lungs, and in the black, stinking fume thereof nearest resembling the horrible Stygian smoke of the pit that is bottomless" -- 1604, James I of England, "A Counterblaste to Tobacco"
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Tobacco Today – Recent History Beginning of 20th Century – A MAN’s pastime - Cigars and pipes (often high society) - chewing in rural areas (still today) Cigarettes! - WW I - 1920's - women wanted to share the privilege - advertisements - WW II - large increase in use - 1950’s - Early studies linking with cancer - Early 60’s – peak use in USA ~40% adults - 1964 -Surgeon General's 1 st warning - 1971 - TV ads banned – cowboy - 1983 - Cigarette tax doubled - 1984 - warning labels - Current USA use ~20-25% of adults (less educated) - Tobacco Settlement (Pitt: $10 Million/3 yrs)
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Carbon monoxide Tar: Carcinogens Free radicals Nicotine – addictive, licit. Second Hand smoke - exhaled (Sidestream smoke – off cigarette) Tobacco Smoke Tobacco Smoke
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Transdermal Transdermal Patch Patch Inhalation Inhalation Cigs, etc Cigs, etc Buccal Buccal Chaw! Chaw! Nicotine Routes of Administration Nicotine Routes of Administration Intranasal Intranasal Snuff Snuff
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Regular smokers: metabolism African-Americans: metabolism Exercise nicotine metabolism Nicotine Pharmacokinetics Nicotine Pharmacokinetics Inhalation: to brain 7 sec Peak 10 min Half-life : 30 min-2 hours Metabolized by liver Main metabolite = cotinine
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Nicotine Pharmacokinetics Nicotine Pharmacokinetics
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Nicotine Structure Nicotine Structure
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Nicotine - Nicotine "Smoking is a custom loathsome to...

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