Cocaine and Amphetamines

Cocaine and Amphetamines - Lecture 10 Cocaine and...

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Lecture 10 Cocaine and Amphetamines
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Stimulants - Increase activity in central nervous system - energy, alertness, talkativeness, sense of well-being - Sympathetic nervous system stimulation - increased heart rate and blood pressure - dilation of bronchioles
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Stimulant Drugs Cocaine Amphetamine Ephedrine Methylphenidate (Ritalin) Pseudoephedrine (Sudafed) Caffeine Nicotine Q: What Federal Law just changed the availability of many of these products? Why?
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Stimulants - Dangerous drug combinations easy - over-the-counter cold remedies with decongestants - monoamine oxidase inhibitors - cocaine - drugs that affect heart rhythm - drugs that make people more sensitive to seizure
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Cocaine History Used by South Americans for at least 5,000 years - religious, social, and medicinal purposes Leaf Chewing (0.6-1.8%)
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Used widely in Europe starting in mid-1800’s Used widely in Europe starting in mid-1800’s
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The intellectual and temperance drink (1885)
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Controlled substance Controlled substance Considered medicinal: - cocaine itself is classified as a local anesthetic. Derivatives: procaine (Novocaine) lidocaine (Xylocaine) Cocaine Today…
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Cocaine use (%) - Past Month
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Medical Uses Medical Uses Cocaine - Local Anesthetic Amphetamine - Asthma - Narcolepsy - Weight loss (although not as common today) - ADHD
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Cocaine structure
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Paste Also: Speedballs
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Cocaine
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Amphetamines Originally derived from ephedrine in Chinese tea from the plant ma huang Introduced into Western culture in 1880 Currently ephedrine many OTC medications Amphetamines - 1920's Search for better ephedrine Amphetamine is the parent compound of many psychostimulants and hallucinogenic drugs.
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Pseudoephedrine? Purified racemic mixture Amphetamines
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This note was uploaded on 04/15/2008 for the course NROSCI 0081 taught by Professor Armandosignore during the Spring '08 term at Pittsburgh.

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Cocaine and Amphetamines - Lecture 10 Cocaine and...

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