Tolerance, Dependence

Tolerance, Dependence - Lecture 7 Tolerance, Withdrawal,...

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Lecture 7 Tolerance, Withdrawal, & Dependence
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Lecture 7 Objectives: 1. Drug Use: Brain Changes 1. 1. Tolerance Tolerance 2. 2. Dependence Dependence 3. 3. Withdrawal Withdrawal 1. Brain's reward system ( reinforcement reinforcement ) 1. Drug craving craving
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Tolerance Tolerance : : = = diminished diminished response to drug administration response to drug administration after after repeated exposure repeated exposure to that drug. to that drug. Tolerance manifests itself as: 1. Using a drug repeatedly, eventually causes the same dose of a drug to produce a lesser effect And/Or 2. When a higher dose of the drug is needed to achieve the same level of the drug’s effect
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Tolerance Tolerance (set) (often true of side effects-morphine)
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Drug Effect Dose (mg) Dose (mg) First First use use Later Later use use Tolerance What has changed? A B
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Drug Effect Dose (mg) Dose (mg) Tolerance First First use use Later Later use use What has changed?
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Drug Effect Dose (mg) Dose (mg) First First use use Later Later use use Tolerance Danger: Danger: Closer to Closer to Side Effects! Side Effects! A B *Therapeutic Index
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Dose Seconal (mg) 0 1000 Time (months) 0 12 Margin of safety* Overdose Sleep Tolerance *Therapeutic Index secobarbitol
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Tolerance a drug’s characteristics a drug’s characteristics Amount, dose Amount, dose frequency frequency duration of use duration of use individual variabilty individual variabilty set set (expectations) (expectations) setting setting
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Types of Types of Pharmacological Tolerance Pharmacological Tolerance 1. Metabolic Metabolic ( ( pharmacokinetic pharmacokinetic ) ) Drug Disposition Tolerance Drug Disposition Tolerance 2 . . Functional
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This note was uploaded on 04/15/2008 for the course NROSCI 0081 taught by Professor Armandosignore during the Spring '08 term at Pittsburgh.

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Tolerance, Dependence - Lecture 7 Tolerance, Withdrawal,...

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