Narcotics-Opiates

Narcotics-Opiates - Lecture 16 Opiates/Narcotics & Pain...

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Unformatted text preview: Lecture 16 Opiates/Narcotics & Pain Seed capsule of opium poppy Papaver Somniferum – “the poppy that causes sleep” nociceptors hair touch/pressure receptors cerebral cortex thalamus from brain to brain Muscle fibers Motor nerve fibers Dorsal horn Ascending Pain Sensation, Reflex PAG = Para Aqueductal Grey Descending pain control system Endogendous Peptide Neurotransmitters: Endorphins Dynorphins Enkephalins Substance P Neurokinin receptors Naked Mole Rats lack Substance P and do not feel pain when painful stimuli are administered to the skin. Painful Stimulus Opiate receptors Mu - μ Delta - δ Kappa - κ Mixed types of opiates: Some opiates are agonists at one receptor subtype, but an antagonist at others.- Buprenex, Nalbuphine, Pentazocine. Opiate Receptors Opiate Receptors Ca+ Decrease cAMP Increase K + 2+ IV TRKA/ NGFR 1q21 R Congenital, or Early childhood Sensory neuropathy Anhidrosis C-axon V R Congenital, or Early childhood Absence of pain No anhidrosis Aδ-axons Absent pain NGF- β 1p13 R Early childhood to Adult Absence of pain No anhidrosis Aδ- & C- axons Inability to ex SCN 9A 2q24 R Congenital Absence of pain No anhidrosis None Erythromelagia SCN 9A 2q24 D Childhood Pain, distal Episodic None HSN Disorder...
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This note was uploaded on 04/15/2008 for the course NROSCI 0081 taught by Professor Armandosignore during the Spring '08 term at Pittsburgh.

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Narcotics-Opiates - Lecture 16 Opiates/Narcotics & Pain...

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