Electrical Properties of Neurons

Electrical Properties of Neurons - Lecture 4 Electrical...

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Lecture 4 Electrical Properties of Neurons
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Q. What mechanisms do neurons use to communicate with each other and their targets? (transfer data). Target: Muscle, another neuron…
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Q. What mechanisms do neurons use to communicate? Electrical Impulses Electrical Impulses - within themselves Chemical Neurotransmission Chemical Neurotransmission - between a neuron and its target
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Most cells in the body are Most cells in the body are electrically electrically neutral neutral (or near neutral). (or near neutral).
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Neurons are electrically Neurons are electrically ACTIVE ACTIVE . . actually, so are muscles…that is how they move. actually, so are muscles…that is how they move.
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Electrochemical Gradient of the Neuron Electrochemical Gradient of the Neuron ~ like a cellular battery - cell is Polarized (in 2 ways) - Resting Membrane Potential (Vm)
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Intracellular (cytoplasm) Extracellular Fluid (outside the neuron) “at rest” -70 mV, inside relative to outside K+ K+ Na+ Na+ Cl- Cl- A- A- K+ K+ Na+ Na+ Cl- Cl- K+ K+ K+ K+ Na+ Na+ Na+ Na+ Cl- Cl- Cl- Cl- A- A- A- A- A- A- A- A- A- A- A- A- A- A- A- A- A- A- ….. ….. ……. ……. ….. ….. Ions: Na = Sodium K = Potassium Cl = Chloride A = Anions, organic acids Electrochemical Electrochemical Gradient Gradient
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The sodium and potassium gradients for a resting membrane Sodium ions are more concentrated outside the neuron; potassium ions are more concentrated inside. However, because the body has far more sodium than potassium, the total number of positive charges is greater outside the cell than inside. Protein and chloride ions (not shown) bear negative charges inside the cell. At rest, very few sodium ions cross the membrane except by the sodium-potassium pump. Potassium tends to flow into the cell because of an electrical gradient but tends to flow out because of the concentration gradient .
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Ion Concentration Gradients Energy $$$ Dependent!
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Electrically ACTIVE …how?
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Electrical Properties of Neurons - Lecture 4 Electrical...

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