Brooker_Chp3CP - Courtesy of The Archives, CIT Reciprocal...

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Chapter 3 Sex Chromosomes Chromosome Theory of Inheritance
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Chromosomes Autosomes = all chromosomes not  involved in determining “sex” Humans:  Chromosomes 1 through 22 Sex chromosomes = chromosomes that  Human males: X  Y  [heterogametic] Human females: X  X [homogametic] X and Y act as homologous  chromosomes during meiosis
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Chromosome Theory of Inheritance Microscopic observations Experimental observations involving  manipulation of gametes Thomas Hunt Morgan showed trait  “followed” X chromosome
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Different Mechanisms Determine Sex Homogametic  Heterogametic
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X – Y Chromosome  Inheritance Male phenotype ‘follows’ Y chromosome
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Columbia University, 1919 Courtesy of The Archives, California Institute of Technology
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Mutant white-eyed male fly – provided ‘tool’ that  showed chromosomes carried the ‘information’  of inheritance
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Unformatted text preview: Courtesy of The Archives, CIT Reciprocal cross : reversing the phenotype of parents female male Initial cross Reciprocal cross Identical results ?? Gene on autosome Different results ?? Gene on sex chromosome T. H. Morgans first fly cross with mutant male fly White-eyed male x true-breeding red-eyed female All red-eyed flies in F 1 NOTE: Drosophila convention F 1 x F 1 cross: White eyes observed only in male flies Observation consistent with hypothesis that eye color is controlled by region(s) on X chromosome Morgans Experiments w/ White-eyed Fly Backcross: F1 females mated with Parental male P F 1 F 2 Backcros s Reciprocal cross proved sex-chromosome linkage White-eyed female x red-eyed male White-eyed males in F 1 Taken together, proved chromosome theory of inheritance...
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This note was uploaded on 04/16/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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Brooker_Chp3CP - Courtesy of The Archives, CIT Reciprocal...

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