Brooker_Chp12P - Chapter 12 Gene Transcription...

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Unformatted text preview: Chapter 12 Gene Transcription & RNA Modification Overview of Gene Expression Other small RNAs Prokaryotes RNA of RNaseP Eukaryotes snRNAs snoRNAs siRNAs telomerase RNA Prokaryotic Transcription Overview of Prokaryotic Transcription Monocistronic mRNA vs. Polycistronic Transcription: Initiation, Elongation, Termination Promoter sequences bind RNA polymerase Consensus sequences upstream = -35 region and -10 region (Pribnow box) Template strand of DNA vs. Coding strand of DNA Escherichia coli RNA polymerase Bacteria have only 1 RNA polymerase- 4 polypeptide chains: 2 , 1 , 1 - core enzyme Multiple sigma factors [i.e. transcription factor]- locate regions upstream of gene(s) - promoter region Core enzyme + sigma = holoenzyme Transcription factors are proteins that interact with DNA sequences; then other proteins This particular transcription factor is classified as a helix-turn-helix motif. Major groove Minor groove Initiation of transcription in bacteria Sigma factor is released, reused to bind / position more RNA polymerases Elongation of RNA transcripts Just like DNA polymerase, RNA polymerase synthesizes 5 -> 3 Note: Template & coding strands Termination of prokaryotic...
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This note was uploaded on 04/16/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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Brooker_Chp12P - Chapter 12 Gene Transcription...

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