Brooker_Chp14P - Chapter 14 Regulation of Gene Expression...

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Chapter 14 Regulation of Gene Expression in  Bacteria & Bacteriophage
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Gene Regulation:   Constitutive vs. Regulated Constitutive gene expression:  constant  transcription – translation - tRNA & rRNA genes - Selected metabolic proteins; e.g. glycolytic enzymes  Regulated gene expression: transcription –  translation limited to cell needs - Specialized metabolic enzymes - Genes needed to respond to environmental changes Efflux pumps to remove antibiotic from cell
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Levels of Gene Regulation in  Bacteria
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Transcriptional control by repressors
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Transcriptional control by activators
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Bacterial Operon:  Multiple genes controlled by a  single regulatory region [promoter + operator] Repressor protein  binds to operator 
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Polycistronic mRNA encodes multiple proteins Each gene has its own start (AUG) codon and its own stop codon. 
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Lactose ( lac ) Operon Catabolic pathway
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Escherichia coli  growing in absence of  lactose as carbon source Negative regulation repressor blocking  transcription NOTE: ‘occasional’, rare  transcription when  repressor momentarily  releases operator Biology
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Escherichia coli  growing in presence of  lactose as only  carbon source Induction:  repressor ‘prefers’ binding to allolactose;  repressor can no longer bind to operator region Biology
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Dissecting Control of the  lac  Operon
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This note was uploaded on 04/16/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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Brooker_Chp14P - Chapter 14 Regulation of Gene Expression...

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