Brooker_Chp15P - Chapter 15 Gene Regulation in Eukaryotes...

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Chapter 15 Gene Regulation in Eukaryotes
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Multiple levels of gene regulation in eukaryotic cells
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Types of transcriptional gene regulation:   Positive Regulation Positive regulation:   -  Activator proteins ‘assist’ transcription -  Up regulation - Enhancer sequences  act in  cis
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Types of transcriptional gene regulation:   Negative Regulation Negative regulation: -  Repressor protein ‘blocks’ transcription -  Down regulation - Silencer sequences  act in  cis
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Structural domains found in transcription  factors α  helix (secondary protein structure) found in different TFs Note:  homodimer
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Structural domains found in transcription  factors 4 Zinc-fingers associated w/ dsDNA:   each with  α  helix and  β -pleated  sheet domains
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Structural domains found in transcription  factors Leucine zipper homodimer with  α  helix
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Remember transcription in eukaryotes?? Involves several transcription  factors Trans -acting factors
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Initiation of basal transcription in eukaryotes (continued) CTD = carboxyl terminal domain TF IIH functions as  helicase & kinase
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Mechanisms of action by transcriptional regulators:   interaction with TFIID Interaction with enhancer  sequence  up regulates (increases) transcription Interaction with silencer  sequence down  regulates (decreases) transcription
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Brooker_Chp15P - Chapter 15 Gene Regulation in Eukaryotes...

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