Unit 5 Use of Hazardous Materials in Animal Reserach

Unit 5 Use of Hazardous Materials in Animal Reserach -...

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Physical, Biological, Chemical and Radiological Hazards Research Protocols may introduce toxic chemicals, pathogens or radioactive materials into animals. These hazards may be present in the animal's blood and tissues and may be shed in the urine, feces and saliva contaminating the bedding, cages and environment. It is the responsibility of the Principal Investigator to assure that research is carried out safely. Potential hazards must be determined before beginning an experiment. Research staff, animal care workers, technicians and other employees at risk must be informed of the hazards and be aware of the necessary precautions that would need to be taken. Basic Principals of Laboratory Hygiene and Safety Initial Evaluation of an Animal Project that Involves Hazardous Materials What materials, equipment, and personnel will be needed? How will these be used? Where will the project be carried out? What can go wrong and what would be the consequences? How likely are these events? How will the project be terminated and what will happen to the waste? What decontamination is needed? How to Evaluate a Project? 1) Recognition 2) Risk assessment 3) Control Recognition What is the hazard? What are its properties? What harm can it cause? Types of Chemical Hazards -Toxic, e.g. carcinogens, teratogens, mutagens -Flammable -Reactive -Corrosive -Sensitizer Types of Biohazardous Materials -Microorganisms bacteria, fungi, viruses -Prions -Toxins -Recombinant DNA and RNA -Animal borne diseases (zoonotic) Questions to ask in evaluating a chemical hazard What are the hazards associated with the parent compound? Are any of the metabolic products of the material hazardous? Is the chemical or its metabolic products excreted by the animal and/or present in organs, tissues or fluids such as blood?
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  • Spring '14
  • Olson,JR
  • Occupational safety and health, Environmental Health and Safety, Principal Investigator, Principals of Laboratory Hygiene and Safety, Chemical and Radiological Hazards

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