Unit 5 Use of Hazardous Materials in Animal Reserach

Unit 5 Use of Hazardous Materials in Animal Reserach -...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Physical, Biological, Chemical and Radiological Hazards Research Protocols may introduce toxic chemicals, pathogens or radioactive materials into animals. These hazards may be present in the animal's blood and tissues and may be shed in the urine, feces and saliva contaminating the bedding, cages and environment. It is the responsibility of the Principal Investigator to assure that research is carried out safely. Potential hazards must be determined before beginning an experiment. Research staff, animal care workers, technicians and other employees at risk must be informed of the hazards and be aware of the necessary precautions that would need to be taken. Basic Principals of Laboratory Hygiene and Safety Initial Evaluation of an Animal Project that Involves Hazardous Materials What materials, equipment, and personnel will be needed? How will these be used? Where will the project be carried out? What can go wrong and what would be the consequences? How likely are these events? How will the project be terminated and what will happen to the waste? What decontamination is needed? How to Evaluate a Project? 1) Recognition 2) Risk assessment 3) Control Recognition What is the hazard? What are its properties? What harm can it cause? Types of Chemical Hazards -Toxic, e.g. carcinogens, teratogens, mutagens -Flammable -Reactive -Corrosive -Sensitizer Types of Biohazardous Materials -Microorganisms bacteria, fungi, viruses -Prions -Toxins -Recombinant DNA and RNA -Animal borne diseases (zoonotic) Questions to ask in evaluating a chemical hazard What are the hazards associated with the parent compound? Are any of the metabolic products of the material hazardous? Is the chemical or its metabolic products excreted by the animal and/or present in organs, tissues or fluids such as blood?
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.
  • Spring '14
  • Olson,JR
  • Occupational safety and health, Environmental Health and Safety, Principal Investigator, Principals of Laboratory Hygiene and Safety, Chemical and Radiological Hazards

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern