1-PK-January-2016-PUBLISH - Principles of Pharmacokinetics...

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Dimensional Analysis for Meds
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Chapter 14 / Exercise 1
Dimensional Analysis for Meds
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Principles of PharmacokineticsHarvey Berman, PhD, MPH
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Dimensional Analysis for Meds
The document you are viewing contains questions related to this textbook.
Chapter 14 / Exercise 1
Dimensional Analysis for Meds
Curren
Expert Verified
ReadingKatzung’s Basic and Clinical Pharmacology, Chapter 3To find HUBNET:MyUB Library Databases “H” HUBNET e-Books Access MedicineAccess Pharmacy
ObjectivesTo understand the kinetic components that underly elimination of drugs after absorption:ClearanceVolume of distributionHalf-lifeBioavailabilityLoading doseMaintenance dose
CompartmentsCompartmentsCompartmentsCompartmentsCompartments
What is volume of distribution?
VD: ExampleGiven:Plasma drug concentration = 10 mg/LAmount of drug in body = 1000 mgWhat is VD?VD=Dose of the drug[Drug]plasma=1000 mg10 mg/L=100 L
Volumes of distributionCompartment and Volume V (70 kg) Examples of drugs Water Total body water (0.6 L/kg) 42 L Small water-soluble molecules; e.g., ethanol Extracellular water (0.2 L/kg) 14 L Larger water-soluble molecules; e.g., gentamicin Blood (0.08 L/kg) Plasma (0.04 L/kg) 5.6 L 2.8 L Strongly plasma protein-bound molecules and very large molecules; e.g., heparin Fat (0.2-0.35 L/kg)14 - 24.5 L Highly lipid-soluble molecules; e.g., DDT Bone(0.07 L/kg) 4.0 L Certain ions; e.g., lead, fluoride
Two limiting casesDrug bound tightly to tissue proteins and not by blood proteinsMost of drug appears to be in large volumeLipid soluble drugs: ImipramineChlorpromazine Drug is tightly bound to plasma protein and not to tissue componentsVDapproximates blood volumeWarfarin What determines VD?

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