parkinson_s_disease - PARKINSONS DISEASE Neica Joseph Due...

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PARKINSON’S DISEASE Neica Joseph Due: 5/20/2015 Honors Biology Period 2
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WHAT IS THE GENETIC BASIS/WHAT GENE CAUSE IT? Parkinson’s disease is a disorder of the central nervous system that affects movement, often including tremors. Our genetic material or genes determine what we look like. Everything from what color your hair color is and what you look like. We have two copies of every gene: we inherit one copy, one member of each pair, from our mother and the other from our father. We then pass only one copy of a gene from each pair of genes to the next generation. Seven genes of Parkinson’s have been identified from genetic mutations. Mutations in genes called SNCA (PARK1), UCHL1 (PARK 5), and LRRK2 (PARK8) and another mapped gene (PARK3) have been reported in families with dominant inheritance. Mutations in three known genes, PARK2 (PARK2), PARK7 (PARK7), and PINK1 (PARK6) have been found in affected individuals who had siblings with the condition but whose parents did not have Parkinson's disease (recessive inheritance).
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HOW DO PEOPLE INHERIT PARKINSON’S DISEASE? Inheriting a non-working copy of a single gene will not cause someone to develop Parkinson's disease. Additional genes and environmental factors determine who will get the condition, when they get it and how it affects them. Some people who inherit the gene develop the condition and others live their entire lives without showing any symptoms. It is not fully know yet to how they inherit this disease.
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HOW IS PARKINSON’S DISEASE DIAGNOSED? No tests exist to diagnose Parkinson's disease. Your doctor trained in nervous system conditions (neurologist) will diagnose Parkinson's disease based on your medical history, a review of your signs and symptoms, and a neurological and physical examination.
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