HumBio3A.2016.Lect.5.ETC+and+ATP+synthesis.Fuller

HumBio3A.2016.Lect.5.ETC+and+ATP+synthesis.Fuller - The...

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1/10/16 1 The Electron Transport Chain and ATP synthesis: May the proton motive force be with you M. T. Fuller ECB3: Ch 14 pp. 447-469 or ECB4: Ch 14 pp. 453 – 476 Respiration and ATP synthesis Last Thursday Glycolysis and the Citric Acid Cycle Today Electrons from NADH to the cytochrome proteins Onward to oxygen where 217 kj of energy is released per mole of NADH The proton gradient and proton pumps ATP synthase, a rotary molecular motor Figure 13-11 ECB3 (© Garland Science 2010) One turn of the Citric Acid Cycle 2CO 2 NADH + H + + 1/2 O 2 NAD + + H 2 O G = - 217 kJ and 3 NADH 1 GTP 1 FADH2 (Oxidized) (Reduced) Pyruvate + Coenzyme A
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1/10/16 2 Figure 14-5 Essential Cell Biology (© Garland Science 2010) Oxidized (lost electrons) Reduced (took electrons) H plus e- from CA cycle intermediates H to Water + Citric Acid Cycle Cytochromes in respiratory chain NAD NADH H 2 O O 2 In mitochondria, 3 cyclic processes are coupled to transport electrons Problem: Sprinting requires 60 µ moles of NAD per gram of muscle per minute, but a muscle only has 1 µ mole of NAD per gram. Mitochondria are the powerhouse of the cell Note double membrane ECB3 Figure 1-18 (@2010 Garland Science) Matrix: Site of CA cycle Cristae: expanded inner membrane, locus of cytochrome based electron transport chain Lots of surface area, right next to the matrix
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1/10/16 3 Dissecting proteins from the inner mitochondrial membrane Cytochrome C Coenzyme Q Figure 14-9 Essential Cell Biology, 3/e.
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