HB3A.16.Lect.21.Cells+to+Organisms

HB3A.16.Lect.21.Cells+to+Organisms - From cells to...

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1 From cells to organisms: How does cell division produce different cell types? (and put them in the right place) Lodish 6e: Ch 21 pp.905-908, 930-931 + Fig. 21-28; MBoC 5e: Ch 22 pp.1305-1320 Two Movies Great Transformations - Discovery of genes that regulate embryonic body pattern. Starring Matthew Scott, Michael Levine and Bill McGinnis Life s Greatest Miracle by Lennart Nilson Amazing in vivo shots of human development. How do embryos develop from a fertilized egg? Lodish V Figure 1.0
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2 Behaviors of cells underlie embryonic development Differential Gene Expression A D V P Pax6 specifies build an eye Pdx1 for pancreas How do you get a regulatory switch gene expressed in the right place? A combinatorial code gets the regulatory switch gene turned on in the right place A D V P
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3 Regulatory Switch Gene Protein coding region Modular control regions integrate information about position on the body axes to turn on regulatory switch genes at the right place D/V Signaling pathway A/P Transcription factor +
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4 Cells and their interactions Differential gene expression History matters 3A - Development of Embryos 3B - Development of Behavior Common Themes: A series of developmental choices leads to differentiation of a specific cell type
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