HumBio3A_Talbot_Feb9 - Epigenetics and the long-term...

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2/8/16 1 Epigenetics and the long-term control of cell fates Overview of cellular memory mechanisms Chromatin modifications: Review and role in epigenetic inheritance Tortoise-shell cats (X chromosome inactivation) Honeybees, alligators, and why you like carrots (Environmental influences) The difference between Mom and Dad (Parental Imprinting) Epigenetics: Establishment and inheritance of differences among cells without altering DNA sequence How are different cell fates maintained throughout the life of the organism? Three common mechanisms Positive feedback loops Inheritance of DNA methylation patterns Inheritance of chromatin states
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2/8/16 2 Figure 8-20 Essential Cell Biology (© Garland Science 2010) A positive feedback loop can generate a long-lived change in gene expression (“cellular memory”) in response to a transient signal Figure 8-21 Essential Cell Biology (© Garland Science 2010) Methylation of cytosine bases in DNA can repress transcription
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2/8/16 3 Figure 8-22 Essential Cell Biology (© Garland Science 2010) DNA methylation patterns can be faithfully inherited
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  • Fall '13
  • Talbot
  • DNA

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