3+Kim+HUMBIO-3A+lecture+Fasting+and+DM+2016

Humbio 3A February 3 2016 Seung Kim Fasting and integration...

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Fasting and integration of physiological responses by glucagon signaling; the connection to diabetes mellitus Humbio 3A February 3, 2016 Seung Kim
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Effects of excess insulin
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The constant specter of starvation ….we must have energy. From The World According to Garp by John Irving
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In mammals, endocrine cells from the pancreas regulate glucose homeostasis Islet β - cells make insulin, a 51 residue polypeptide hormone α -cells make glucagon a 29 residue polypeptide hormone
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Glucagon structure Like for insulin there is evolutionary conservation of glucagon and its receptor in metazoans.
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How is islet α -cell secretion of glucagon regulated?
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16_16_Gprotein_linkd .jpg Receptor for glucagon; 7 transmembrane protein, GPCR
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G protein-coupled receptor signaling like from the glucagon receptor results in second messengers like cAMP
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Figure 16-23 Essential Cell Biology (© Garland Science 2010)
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