Week+8+Pre-Section+Assignment

Week+8+Pre-Section+Assignment - Hox10 and its interaction...

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W ELLIK & C APECCHI P APER P RE -S ECTION A SSIGNMENT Label the diagram below using the following terms: Cervical, Sacral, Lumbar, Thoracic What do the letters (A/a, B/b, C/c, D/d) refer to in the names of the mutants in this paper? Consider the effects of mutating Hox10 on A/P patterning: 1. What was the phenotype of the 10aaccdd mutant along the A/P axis? 2. What was the phenotype of the mice with only 5 mutated alleles (10Aaccdd)? 3. What does the 10aaccdd mutant tell us about the normal function of
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Unformatted text preview: Hox10 and its interaction with more anterior Hox genes? Consider the effects of mutating Hox11 on A/P patterning: 1. What was the phenotype of the 11aaccdd mutant along the A/P axis? 2. What was the phenotype of the mice with only 5 mutated alleles (11aaCcdd)? 3. What does the 11aaccdd mutant tell us about the normal function of Hox11 and its interaction with Hox10 ?...
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