Class5 - Class#5 Chemistry(continued Proteins and Lipids...

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Unformatted text preview: Class #5: Chemistry (continued...) Proteins and Lipids Cell Structure & Function: Cell Membranes Macromolecules Polymers 3 Polysaccharides 3 Nucleic acids Proteins* Lipids (DNA, RNA)* Monomers Simple sugars or carbohydrates Nucleotides Amino acids Fatty acids (& other molecules) *Informational macromolecules: the sequence carries information THE Barrier Cell Membranes Membranes have proteins embedded in a lipid bilayer Critical functions of membranes - separate cell from its environment (act as a barrier) and control traffic of nutrients, proteins etc. in & out of cells - transport Proteins Proteins are polymers of amino acids Chemical properties Amino Acids Amino Acids Proteins Amino acids are linked via peptide bonds to form dipeptides... loss of H2O Y dehydration reaction ...polypeptides Amino Acids Proteins Amino acids are linked via peptide bonds to form polypeptides. Polypeptide = linear array of amino acids Protein = one or more polypeptides Protein Structure Protein = one or more polypeptides Structure: 1 -- linear sequence of amino acids 2 -- e.g., a-helix, -sheet 3 -- folding of secondary structure 4 -- arrangement of polypeptides Protein o 2 Structure -sheet a-helix Protein o 3 Structure Protein o 4 Structure Human Hemoglobin: Protein o 4 Structure Cellulase Enzymes: Cellulosomes 50 nm 0.5 m Clostridium thermocellum. Arrows indicate clumps of cellulosomes (polycellulsomes) Protein Denaturation Ribonuclease Macromolecules Polymers 3 Polysaccharides 3 Nucleic acids 3 Proteins* Lipids Lipids (DNA, RNA)* Monomers Simple sugars or carbohydrates Nucleotides Amino acids Fatty acids (& other molecules) *Informational macromolecules: the sequence carries information This group H is found in all: amines hydrocarbons organic acids inorganic acids Lipids carboxylic acid Lipids Lipids Phospholipids - membrane essentials hydrophilic hydrophobic Lipids Phospholipids - membrane essentials Lipids Bacteria Archaea Isoprene Lipids & Membranes Archaea Membranes Bacteria Halorhodospira halochlora phototroph Membranes - Function Membrane Transport Membrane Transport Simple Transporter Proton Motive Force Membrane Transport Group Translocation e.g., Phosphotranspherase System Membrane Transport ABC Transport System ABC = ATP-binding cassette Involves three components Membranes Membranes: the most advanced traffic control device in biology. ...
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This note was uploaded on 04/18/2008 for the course MICROBIO 310 taught by Professor Dolan during the Spring '08 term at Univ. of Massachusetts Med. School.

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