Pharm Final

Pharm Final - Antibiotics Infecting organism must be...

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Antibiotics Infecting organism must be identified – should do a culture and sensitivity Assess and support host defense mechanisms (person’s immune system) – change dressings frequently, put drains in wound, make sure adequate nutrition Proper dose and administration of therapy – want to maintain blood levels Avoid mixing drugs to avoid incompatibilities Bacterial resistance – over time an organism that was once highly responsive to an antibiotic may become less susceptible or become immune entirely o Mechanisms May produce drug-metabolizing enzymes May cause a decrease of drug uptake by cell Drug receptors may change resulting in decreased antibiotic binding and action May synthesize compounds that antagonize drug actions o Broad-spectrum antibiotics facilitate resistance more than narrow-spectrum drugs* o Measures to delay emergence of resistance – only use antibiotics when needed, use narrow-spectrum when possible, newer antibiotics should be reserved for
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This note was uploaded on 04/18/2008 for the course NU 204 taught by Professor Fairchild during the Spring '08 term at BC.

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Pharm Final - Antibiotics Infecting organism must be...

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