Bchm2000_L4 OxidativePhosphorylation_instructor

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https:// www.youtube.com/watch?v=JP Cs5pn7UNI TCA cycle Biochemistry 2000
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Biochemistry 2000 Oxidative Phosphorylation Voet Biochemistry: Chapter 22, Pages 823 - 859 Voet Fundamentals: Chapter 18, Pages 596 – 629
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Fates of Pyruvate Biochemistry 2000 2 x Pyruvate 8 x NADH 2 x FADH 2 2 x GTP Each Glucose 2 x NADH 2 x ATP
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Metabolic Summary Glycolysis is one of two major metabolic pathways that convert carbohydrates into energy and simpler compounds Pyruvate (under aerobic conditions) enters Citric Acid Cycle (in mitochondrion): generates 8 NADH, 2 FADH 2 , 6 CO 2 and 2 GTP (= 2 ATP) per 2 pyruvate (1 glucose) NADH and FADH 2 enter oxidative phosphorylation pathway Proteins and Lipids are broken down and also eventually enter glycolysis and the citric acid cycle Biochemistry 2000
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Glucose “combustion” “In general, respiration is nothing but the slow combustion of carbon and hydrogen, which is entirely similar to that which occurs in a lamp or lighted candle ... “ (Seguin & Lavoisier, 1789) Combustion of Glucose C 6 H 12 O 6 + 6 O 2 6 CO 2 + 6 H 2 O Electron Transfer in Glucose Combustion C 6 H 12 O 6 + 6 H 2 O 6 CO 2 + 24 H + + 24 e - (glucose oxidation) 6 O 2 + 24 H + + 24 e - 12 H 2 O (oxygen reduction) In living system, the electrons of glucose are not transferred directly to oxygen. Rather they are transferred in a multistep pathway that harnesses the libertated energy to form ATP. Biochemistry 2000
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Oxidation / Reduction (Redox) Reactions Review Redox reactions are all chemical reactions in which atoms change their oxidation state (hypothetical charge if all bonds are ionic) Typically involves transfer of electrons from one molecule, atom or ion to another
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