Lecture 6 - Solute and Water Movement Across Membranes Spring 08

Lecture 6 - Solute and Water Movement Across Membranes Spring 08

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Distribution of Water and Solutes in the Body Distribution of solutes depends on whether substance can cross cell membrane by simple diffusion or whether it needs a membrane protein or vesicle to move across Cell membranes are selectively permeable – cell can select which molecules will enter and which will leave by varying lipid composition and the protein transporters of its membrane Selective permeability of cell membranes creates a body in which intracellular and extracellular compartments are chemically and electrically different but have same total concentrations of solutes Compartments of the body in a state of Chemical Disequilibrium and at the same time in a state of Osmotic Equilibrium
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Diffusion Simple ( passive ) Membrane channels ( passive ) Carrier-Mediated Transport Facilitated transport ( passive ), Active transport ( energy dependent ) Active transport ( energy dependent ) Ways Molecules Move Across Cell Membranes Small, nonpolar, lipid soluble molecules O 2 ,CO 2, steroids, vitamins, * H 2 0 Smaller, water soluble molecules, ions, H 2 0 H 2 0, K + , Na + , Ca 2+ , Cl - , HCO 3 - Larger, uncharged polar molecules Amino acids, glucose
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Lecture 6 - Solute and Water Movement Across Membranes Spring 08

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