Bio notes 6

Bio notes 6 - Zhaonan Liu Bio Lecture 6 Membrane Structure...

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Zhaonan Liu 9/7/07 Bio Lecture 6 Membrane Structure and Function Red blood cell ghosts 1915 1915 Data: Membrane consists of phospholipids and proteins 1925 Data: Stable phospholipid bilayer can self assemble 1935 Data: Membrane is more wettable than a pure phospholipid bilayer Davson & Danielli propose sandwich model with more hydrophilic proteins on the outside 1950s Data: Transmission electron microscopy (TEM) reveals 3 layered sandwich Problems with Davson-Danielli model Data: Cholesterol is present in membranes of eukaryotes, but not in prokaryotes Data: Plasma membrane is 7-8 nm thick, 3 layers but mitochondrial membrane is only 5-6 nm thick and looks like a row of beads, not a sandwich Data: Protein composition differs in different membranes Most inconsistent data: membrane proteins are not very soluble in water and have hydrophobic regions Fluid Mosaic model Prediction: Freeze fracture, transmission electron microscopy (TEM) should reveal proteins embedded in the membrane
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Bio notes 6 - Zhaonan Liu Bio Lecture 6 Membrane Structure...

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