139 13F Circulatory and Lymphatic Systems (1)

139 13F Circulatory and Lymphatic Systems (1) - Circulatory...

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Circulatory and Lymphatic Systems Bio 139 Fall 2013 Dr. Michael W. Thompson
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Outline Vascular structure and types of arteries Capillaries Structure, fenestrations Diffusion in capillaries Forces favoring movement of water out and in Exit of fluids at arterial end of bed Return of fluids at venous end of bed Blood flow in veins Valves Skeletal muscle and respiratory pump Circulatory dynamics and regulation of blood pressure
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Outline Lymphatic system functions Lymph vessels Lymphatic organs Lymph nodes Spleen
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(a) Artery TUNICA INTERNA: (b) Vein Lumen Lumen Endothelium Basement membrane Internal elastic lamina Smooth muscle External elastic lamina TUNICA EXTERNA TUNICA MEDIA: Valve Vascular structure
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The endothelial layer Continuous with endocardium Simple squamous epithelial cells Rests on basement membrane (c) Capillary Lumen Basement membrane Endothelium
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Arteries Conducting (large) arteries Major arteries, like the aorta Distributing (medium) arteries Deliver blood to specific organs/tissues, like the gastric artery Small (branch) arteries Smallest are called “arterioles” Metarterioles Link arterioles to capillary beds Have sphincters that may close off capillary beds Capillaries Thin-walled exchange vessels
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Smooth muscle fiber Endothelium ARTERIOLE METARTERIOLE Precapillary sphincters (relaxed) CAPILLARY MUSCULAR VENULE Endothelium To heart Thoroughfare channel POSTCAPILLARY VENULE Smooth muscle fiber From heart CAPILLARY BED
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Capillary 600x LM Connective tissue (e) Red blood cells passing through a capillary Red blood cell Capillary endothelial cells
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Capillaries Composed of simple squamous epithelium, basement membrane, and layer of loose CT May be continuous or fenestrated Fenestrated capillaries have openings between endothelial cells that allow diffusion
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Continuous Capillary (a) Continuous capillary formed by endothelial cells Pinocytic vesicle Basement membrane Nucleus of endothelial cell Lumen Intercellular cleft
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Fenestrated capillary (b) Fenestrated capillary Fenestration (pore) Intercellular cleft Lumen Pinocytic vesicle Basement membrane Nucleus of endothelial cell
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Diffusion in capillaries Through endothelial cells Lipid soluble molecules, O 2 , CO 2 Between endothelial cells Small water-soluble molecules Through fenestrae Larger, water-soluble molecules; other large molecules (small proteins) Proteins still do not easily leave the capillary!
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Capillary exchange Diffusion controls most movement of materials
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