BMB280 Exam 4 key 2006

BMB280 Exam 4 key 2006 - BMB 280 Exam#4 Thurs TOTAL 95...

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BMB 280 – Exam #4 Name__ _______________ Thurs., May 11, 2006 (Covers Lectures 19-25, Prokaryotic Gene Regulation to Cancer Gene Therapy Page 1 KEY TOTAL 95 POINTS SECTION A. “Multiple Choice” (1 pt each; 20 points total) CIRCLE letter of the ONE BEST answer A1. What enzyme possessed by cancer cells but lacking in normal cells is thought to contribute to the ability of cancer cells to become immortal? a. telomerase b. RNA polymerase c. DNA-directed DNA polymerase d. reverse transcriptase e. RNA-directed DNA polymerase A2 . Mitogen activated protein kinase (MAPK): a. is a calcium-binding protein that inhibits receptor tyrosine kinases. b. is activated by Ca ++ released from the endoplasmic reticulum. c . phosphorylates multiple target proteins involved in regulation of the cell cycle. e. is a GTP-binding protein. A3. During the M phase of the cell cycle: a. the cytoplasm is divided to form two daughter cells. b. DNA damage is assessed before moving to G 1 . d. many mitochondria multiply madly. e. DNA is replicated. A4. All of the following statements are TRUE about oncogenes , EXCEPT: a. oncogenes may be mutant forms of normal cellular genes involved in signal transduction pathways. b. oncogenes promote unregulated cell growth. c. oncogenes include mutant forms of the mitogen-activated protein kinases. d. oncogenes include erb-B, a mutant form of a tyrosine kinase (growth factor) receptor. e. oncogenes include mutant forms of the G-protein ras. f . oncogenes include mutant forms of the tumor suppressor protein Rb. [Rb is a tumor suppressor (negative growth regulator); oncogenes are positive growth regulators] A5. The Rb gene: a. normally functions to inhibit entry into S phase until it is phosphorylated by G1 cdk/cyclins. c. causes warts. d. encodes a protein that cleaves microtubules during Anaphase of Mitosis. . e. can be treated by green tea. .
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BMB 280 – Exam #4 Name__ _______________ Thurs., May 11, 2006 (Covers Lectures 19-25, Prokaryotic Gene Regulation to Cancer Gene Therapy Page 2 KEY c. acetylation, laminins, protein kinase A6. The protein “p53”: a. is a mutant form of a normal cellular tyrosine kinase. b. binds to cyclin to regulate cyclin-dependent protein kinases (CDKs). c. in response to severe DNA damage, may initiate apoptosis (programmed cell death). This was the answer d. phosphorylates the transcription factors fos, jun and ets. A7. Cancer treatments currently under development include methods to stop the proliferation of new capillaries that feed the growing tumor cells, a process called: a. angina b. ataxia c. angiogenesis d. cellulitization e. vesseligenesis A8. Nuclear lamina disassembly prior to mitosis is thought to be induced by _______ of the ______ by a specific ______. a. phosphorylation, lamins, protein kinase b. phosphorylation, lamins, protein phosphatase d. phosphorylation, laminins, protein kinase too tricky, not counted wrong; laminins are part of the basement membrane e. acetylation, lamins, protein acetylases A9. The effect of a protein kinase that adds a phosphate group to a target protein can be reversed by: a. a specific phosphodiesterase.
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This test prep was uploaded on 04/18/2008 for the course BMB 280 taught by Professor Vanbeneden during the Spring '08 term at University of Maine Orono .

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BMB280 Exam 4 key 2006 - BMB 280 Exam#4 Thurs TOTAL 95...

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