3. Sabban - Fatty Acid and Triglyceride Biosynthesis

3. Sabban - Fatty Acid and Triglyceride Biosynthesis - 2....

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Biosynthesis of Fatty Acids •Occurs in Cytosol •Mitochondria not permeable to acetyl CoA, but citrate can leave the mitochondria 1
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Phosphorylated and inactivated by cAMP dependent protein kinase (by glucagon , Epi) Citrate also leads to large polymeric form 4
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Formation of Malonyl CoA by Acetyl CoA Carboxylase is Rate Limiting Step in Fatty Acid Biosynthesis 5
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Fatty Acid Biosynthesis Occurs Bound to ACP 8
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Fatty Acids and Triacylglycerols 11
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Fatty Acid Pathways The Biosynthesis and Degradation Pathways are Diferent • As in cases of glycolysis/gluconeogenesis and glycogen synthesis/breakdown, fatty acid synthesis and degradation go by di±erent routes • There are four major di±erences between fatty acid breakdown and biosynthesis The Di±erences Between Fatty acid biosynthesis and breakdown 1. Intermediates in synthesis are linked to -SH groups of acyl carrier proteins (as compared to -SH groups of CoA
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Unformatted text preview: 2. Synthesis in cytosol; breakdown in mitochondria 3. Enzymes of synthesis are one polypeptide 4. Biosynthesis uses NADPH/NADP + ; breakdown uses NADH/NAD + 14 15 (Malonyl CoA might also suppress appetite) 16 Some recent developments Two genes for acetyl CoA carboxylase, ACC-1 in lipogenic tissues such as liver and ACC-2 more predominant in non-heart and sketetal muscle, thus function in addition to synthesis of fatty acids, such as inhibition of CPT, and entry of fats into mitochondria Increase in malonyl CoA, or supression of fatty acid synthase activity may aFect appetite 17 Note: Mammalian cells cannot introduce double bond beyond C-9 Introduction of Double Bonds in Fatty Acid 18 19 Biosynthesis of Triglycerides 20 21 Structure of a Triglyceride 22 23 24 25 26 27...
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This note was uploaded on 04/18/2008 for the course BIOC 1010 taught by Professor Zhang during the Fall '07 term at New York Medical College.

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3. Sabban - Fatty Acid and Triglyceride Biosynthesis - 2....

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