{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

3. Sabban - Fatty Acid and Triglyceride Biosynthesis

3. Sabban - Fatty Acid and Triglyceride Biosynthesis - 2...

Info iconThis preview shows pages 1–27. Sign up to view the full content.

View Full Document Right Arrow Icon
Biosynthesis of Fatty Acids •Occurs in Cytosol •Mitochondria not permeable to acetyl CoA, but citrate can leave the mitochondria 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2
Background image of page 2
3
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Phosphorylated and inactivated by cAMP dependent protein kinase (by glucagon , Epi) Citrate also leads to large polymeric form 4
Background image of page 4
Formation of Malonyl CoA by Acetyl CoA Carboxylase is Rate Limiting Step in Fatty Acid Biosynthesis 5
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
6
Background image of page 6
7
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Fatty Acid Biosynthesis Occurs Bound to ACP 8
Background image of page 8
9
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
10
Background image of page 10
Fatty Acids and Triacylglycerols 11
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
12
Background image of page 12
13
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Fatty Acid Pathways The Biosynthesis and Degradation Pathways are Di ff erent As in cases of glycolysis/gluconeogenesis and glycogen synthesis/breakdown, fatty acid synthesis and degradation go by di ff erent routes There are four major di ff erences between fatty acid breakdown and biosynthesis The Di ff erences Between fatty acid biosynthesis and breakdown 1. Intermediates in synthesis are linked to -SH groups of acyl carrier proteins (as compared to -SH groups of CoA
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 16
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 18
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 20
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 2. Synthesis in cytosol; breakdown in mitochondria 3. Enzymes of synthesis are one polypeptide 4. Biosynthesis uses NADPH/NADP + ; breakdown uses NADH/NAD + 14 15 (Malonyl CoA might also suppress appetite) 16 Some recent developments •Two genes for acetyl CoA carboxylase, ACC-1 in lipogenic tissues such as liver and ACC-2 more predominant in non-heart and sketetal muscle, thus function in addition to synthesis of fatty acids, such as inhibition of CPT, and entry of fats into mitochondria •Increase in malonyl CoA, or supression of fatty acid synthase activity may aFect appetite 17 Note: Mammalian cells cannot introduce double bond beyond C-9 Introduction of Double Bonds in Fatty Acid 18 19 Biosynthesis of Triglycerides 20 21 Structure of a Triglyceride 22 23 24 25 26 27...
View Full Document

{[ snackBarMessage ]}