2006.05.04 Exam III - Name: General Biochemistry Exam I11...

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Name: General Biochemistry Exam I11 Thursday, May 4th, 2006 4:00 - 6:00 PM Put your name and identification number on the answer sheet. Mark only one answer for each question on the answer sheet. Use only the pencil provided for the examination. Do not fold or bend the answer sheet. Make sure you have 12 question pages. Read each question carefully. 1. Cholesterol is a component of, or metabolized into, all of the following EXCEPT? A. Cholic acid B. Plasma membranes C. Cortisol D. Estradiol E. Vitamin D 2. Which of the following statements concerning cholesterol is FALSE? A. It is hydrophobic B. Its rings are essentially planar C. All of its substit~ients are above the plane of the rings D. The ring system can be enzymatically broken down to yield other substances E. When present in the diet it is largely taken lip by the gastro-intestinal system 3. In the biosynthesis of cholesterol all of the carbon atoms can be traced back to? A. Acetyl CoA B. Carbon monoxide C. Carbon dioxide D. Beta-carotene E. Propionyl CoA 4. Isoprenoid units can be used for the synthesis of all of the following EXCEPT? A. Ubiquinone B. Natural rubber C. Vitamin A D. Vitamin D E. Chlorophyll F. Heme
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5. The first cyclic compound in the biosynthesis of cholesterol is? A. Farnesyl pyrophosphate B. Lanosterol C. Squalene D. Mevalonic acid E. Geranyl pyrophosphate 6. Which of the following statements concerning bile acids is FALSE? A. They contain 24 carbon atoms B. They contain a double bond in ring B C. They contain 1, 2, or 3 alpha hydroxy groups D. They can be conjugated with either glycine or taurine E. In newborns there are only 2 bile acids present 7. Total cellular Hydroxy-methylglutaryl CoA reductase activity is increased in all of the following conditions EXCEPT? A. Low hepatic cellular cholesterol levels B. Nighttime C. Statin treatment D. Insulin stimulation E. Activated SRERP
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For the following questions choose the best answer from the following list. Each choice can be used more than once. For some questions there may be more than one correct answer; if so, choose only one. A. Pregnenolone B. Prednisone C. Cortisol D. Cortisone E. Estrone F. Estradiol G. Estriol H. Aldosterone I. Androstenedione J. Testosterone K. 5 alpha-Dihydrotestosterone L. RU-486 M. R-1881 N. Tamoxifen 0. Raloxifene P. Desmolase Q. 17 alpha-Hydroxylase R. 1 1 beta-Hydroxysteroid Dehydrogenase S. 5 alpha-Reductase T. Aromatase 8. The most potent of the androgens 9. An example of a SERM (selective estrogen receptor modulator) 10. A synthetic glucocorticoid 1 1. A progesterone antagonist 12. A naturally occurring steroid hormone with 19 carbon atoms 13. An enzyme which is a target for pharmacologic inhibition in the treatment of breast cancer 14. An enzyme which is a potential target for phamacologic inhibition in the treatment of prostate cancer
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15. The biosynthesis of heme requires all of the following EXCEPT? A.
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2006.05.04 Exam III - Name: General Biochemistry Exam I11...

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