2005.03.22 Exam II - Name: _ 1 General Biochemistry...

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1 Name: ____________________ General Biochemistry Examination II Tuesday, March 22 nd , 2005 4:00-6:00 PM ! Put your name and identification number on the answer sheet. ! Mark only one answer for each question on the answer sheet. ! Use only the pencil provided for the examination. ! Do not fold or bend the answer sheet. ! Make sure you have ??? question pages. ! Read each question carefully. 1. Regarding malonyl CoA, all of the following statements are correct except A. It is synthesized by a mitochondrial enzyme B. It inhibits entry of long chain fatty acids into the mitochondria C. It is synthesized by a biotin containing enzyme D. It is synthesized from acetyl CoA E. Its synthesis is enhanced by high ATP/AMP 2. How many ATPs can be generated in each cycle of beta-oxidation of a saturated fatty acid (eg from stearoyl CoA to palmitoyl CoA)? A. 12 B. 10 C. 15 D. 14 E. 12.5 3. The cofactor for the redox steps of fatty acid biosynthesis is 1. NADH 2. NADPH 3. FADH 2 4. Ascorbate A. 1 only B. 1 or 2 C. 2 only D. 2 or 3 E. 2 and 3 4. In comparing fatty acid biosynthesis and beta-oxidation, all of the following statements are true except A. They differ in the cofactor(s) used. B. Both processes involve thio ester C. Both involve redox reactions D. They build or degrade the fatty acids two carbons at a time E. Both are regulated by phosphorylation/dephosphorylation
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2 5. The glycerol backbone of triacylglycerides is derived from A. Glucose B. Lactose C. Citrate D. Acetyl CoA E. Acetoacetate 6. Which are involved in absorption and digestion of lipids from the diet? 1. Lipoprotein lipase 2. .Hormone sensitive lipase 3. Pancreatic Lipase 4. Chylomicrons 5. LDL A. 1 and 2 only B. 1 and 3 only C. 1, 3, 4 only D. 1,2, 4 only E. All the above 7. Which of the following steps in fatty acid degradation requires energy? A. Thiolase (last enzyme of ! -oxidation). B. Carnitine palmitoyl transferase I. C. Carnitine palmitoyl transferase II. D. Transport of fatty acids bound to albumin. E. Attachment of coenzyme A to fatty acid. F. Hydration of the enoyl intermediate For questions 8-11. Match: (choices may be used more than once) A. Carnitine B. Beta-hydroxybutyrate C. Citrate D. Fatty acid synthase E. Acetyl CoA carboxylase F. Palmitic acid G. Malonyl CoA H. FADH I. NADH J. NADPH K. Thiokinase 8. Carrier for long chain fatty acyl groups into 9. Rate limiting enzyme in fatty acid biosynthesis 10. Activator of fatty acid biosynthesis 11. A ketone body
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3 12. Which are generated in ß-oxidation of palmitoyl CoA (16:1 " 9 ) in liver is the following A. 8 acetyl CA, 7 NADH, 7FADH 2 B. 1 acetoacetate, 6 acetyl Co A, 7 NADH, 7 FADH 2 C. 8 acetyl CA, 7 NADH, 6 FADH
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This note was uploaded on 04/18/2008 for the course BIOC 1010 taught by Professor Zhang during the Fall '07 term at New York Medical College.

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2005.03.22 Exam II - Name: _ 1 General Biochemistry...

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