11.29 - Rosenfeld - Plasma Proteins & Coagulation

11.29 - Rosenfeld - Plasma Proteins & Coagulation -...

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1 Plasma Proteins 2 3
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16 17 Fibrinogen Reactions: Thrombin Fibrinogen Fibrinopeptides A and B + Fibrin monomers (soluble) XIIIa Fibrin monomers Fibrin polymer (insoluble) Cross linked Fibrin Factor XIIIa is a transglutaminase: O O || || Protein 1 -CH 2 -CH 2 -NH 2 + H 2 N-C-CH 2 -Protein 2 Protein 1 -CH 2 -CH 2 -NH 2 -C-CH 2 -Protein 2 Lysine Glutamine 18
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OSO 3 CH 2 -NH-CH-CO- Sulfotyrosine 19 Nomenclature. The blood coagulation factors are designated by roman numerals, and the proteolytically activated forms are roman numerals followed by small letter "a". Factor Common Name Vitamin K? I Fibrinogen II Prothrombin ……………………………………Yes III Tissue Factor (Thromboplastin) IV Calcium (Ca 2+ ) V Proaccelerin VII Proconvertin, Cothromboplastin ………………Yes VIII Antihemophilic Factor A IX Antihemophilic Factor B, Christmas Factor …….Yes X Stuart Power Factor ……………………………Yes XI Plasma Thromboplastin Antecedent (PTA)
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This note was uploaded on 04/18/2008 for the course BIOC 1010 taught by Professor Zhang during the Fall '07 term at New York Medical College.

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11.29 - Rosenfeld - Plasma Proteins & Coagulation -...

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