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Unformatted text preview: . This would cause fluid to accumulate within the interstitium over time if it were not for the lymphatic system that removes excess fluid from the interstitium and returns it back to the intravascular compartment. Circumstances, however, can arise where net capillary filtration exceeds the capacity of the lymphatics to carry away the fluid (i.e., net filtration > lymph flow). When this occurs, the interstitium will swell with fluid, thereby become edematous. Factors Precipitating Edema Increased capillary hydrostatic pressure (as occurs when venous pressures become elevated by gravitational forces, in heart failure or with venous obstruction) Decreased plasma oncotic pressure (as occurs with hypoproteinemia during malnutrition) Increased capillary permeability caused by proinflammatory mediators (e.g., histamine, bradykinin) or by damage to the structural integrity of capillaries so that they become more "leaky" (as occurs in tissue trauma, burns, and severe inflammation) Lymphatic obstruction (as occurs in filariasis or with tissue injury) Prevention and Treatment of Edema
The treatment for edema involves altering one or more of the physical factors that regulate fluid mo...
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This note was uploaded on 04/18/2008 for the course PHYS 1010 taught by Professor Thompson during the Fall '07 term at New York Medical College.
- Fall '07
- Hydrostatic Pressure