04.02 - Ross - Pain - Pain •Dr. William Ross...

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Unformatted text preview: Pain •Dr. William Ross •Department of Physiology •Room 605 1 12.5 25.0 37.5 50.0 15 - 30 31 - 40 41 - 50 51 - 60 >60 Pain % Pain Prevalence by Age 2 17.5 35.0 52.5 70.0 2.6 3.3 2.6 6.8 17.1 67.0 1m 1 - 3m 3 - 6m 6 - 12m 1 - 3y >3 years % DURATION : Time Since First Occurrence of Pain 3 Pain threshold tolerance threshold dancers nondancers 4 Pain receptors and sensory receptors are different 5 First and second pain are mediated by different fiber types 6 Nociceptors express various receptors 7 ASIC VR1/VRL-1 TRPV1 CMR1 TRPM8 TRP ENaC/DEG Signal transduction in nociceptors VR1 – vanilloid receptor or TRPV1, capsaicin CMR1 – cold and menthol activated receptor or TRPM8 ASIC – acid sensing ion channel 8 Pain receptors are sensitized by the local release of chemicals 9 Behavioral Pain States and Their Cellular Correlates Subject Response Fiber Response Allodynia Hyperalgesia Spontaneous pain Decreased threshold for firing Increased fring to suprathreshold Ectopic Firing Sensitization...
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This note was uploaded on 04/18/2008 for the course PHYS 1010 taught by Professor Thompson during the Fall '07 term at New York Medical College.

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04.02 - Ross - Pain - Pain •Dr. William Ross...

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